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KMID : 0352519830200030037
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Korea Univercity Medical Journal
1983 Volume.20 No. 3 p.37 ~ p.45
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An experimental study of intrauterine administration of Prostaglandin E₂on the ovary and plasma hormone levels in pseudopregnant rabbits
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崔鏡淑/Choi, Kyung-Sook
羅重烈/李壽鍾/Na, Joong-Yol/Lee, Soo-Chong
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Abstract
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The effects of intra-uterine administration of Prostaglandin-E2 on the ovary and plasma steroid hormones were studied. Pseudopregnancy was induced in seven rabbits by the injection of 50ug of ethinyl estradiol and 100IU of hCG subcutaneously. And these seven pseudopregnant rabbits served as control group. In the prostaglandin-E2-treated group, pseudopregnancy was induced with 50pg of ethinyl estradiol and 1001U of hCG, and prostaglandin-E2 was implanted in uterus on Day seven under laparotomy and uterine incision with pentothal anesthesia. The plasma estrogen and progesterone level was determined by radioimmunoassay with three days interval in both control and prostaglandin-E2 treated group.
The uterus and ovaries were submitted to histologic study on Day 30. The following results were obtained;
1. Serum progesterone level in intra-uterine prostaglandin-E2-implanted pseudopregnant rabbits was decreased at 14th day of pseudopregnancy, while the progesterone level of normal pseudopregnant rabbits was decreased from 15th day of pseudopregnancy and returned to normal values by 18th day.
2. Serum estrogen levels of pseudopregnant rabbit was higher than pretreatment state and returned to normal value by 30th day, while, in prostaglandin-E2-treated group, the serum estrogen values was decreased at 11th and 18th day below the level of pretreatment state and it was more decreased at 28th day.
3. The corpus luteum regresses from 15th day in control group, but in prostaglandin-E2 treated group, the corpus luteum was indistinct. The numbers of follicles in control group were 4-5 in number, while, in prostaglandin-E2 treated group, they were increased to 7-11 in number.
The endometrium was papillary secretory patterns in control group, while, in prostaglandin-E2 treated group, the endometrium was shown to have proliferative patterns.
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